Cloning, sequence and mutagenesis of the structural gene of Pseudomonas aeruginosa CysB, which can activate algD transcription

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Pseudomonas aeruginosa infection in cystic fibrosis: nucleotide sequence and transcriptional regulation of the algD gene.

Pulmonary infection by mucoid, alginate producing, Pseudomonas aeruginosa is a major complication in patients suffering from cystic fibrosis (CF). To analyze the mechanisms leading to the emergence of mucoid P. aeruginosa in CF lungs, control of the algD gene coding for GDPmannose dehydrogenase was studied. Transcriptional activation of algD was shown to be necessary for alginate production. Se...

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Loss of Pseudomonas aeruginosa PhpA aminopeptidase activity results in increased algD transcription.

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ژورنال

عنوان ژورنال: Molecular Microbiology

سال: 1997

ISSN: 0950-382X,1365-2958

DOI: 10.1046/j.1365-2958.1997.4121799.x